SB-203580_p38_MAPK_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IS0460-50mg	Inquiry	Inquiry	Inquiry	Inquiry
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CAS	152121-47-6
English Name	SB-203580
Synonym	SB203580;RWJ64809;PB203580;SB203580Hydrochloride;
Unit	Piece
Purity	≥98%
Molecular Formula	C₂₁H₁₆FN₃OS
Molecular Weight	377.43
Appearance	White to light yellow solid
Storage	Store powder at -20℃ for 2 years, in solvent(mother liquid) at -20℃ for 1 month, -80℃ for 6 months.
Solubility	Soluble in DMSO
MDL	MFCD00922198
SMILES	O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
Description	SB-203580 is a selective, ATP-competitive inhibitor of p38 MAPK that also inhibits LCK, GSK3β and PKα. SB-203580 is an activator of autophagy and mitophagy.
Target Point	p38 MAPK，LCK，GSK3β,PKBα，Autophagy, Mitophagy
Passage	MAPK;PI3K/Akt/mTOR;Stem Cells;Protein Tyrosine Kinase/RTK;Autophagy
Data Literature Source	[1]. Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 2000 Mar 10;275(10):7395-402. [2]. Birkenkamp KU, et al. The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br J Pharmacol. 2000 Sep;131(1):99-107. [3]. Su J, et al. SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma. 2010 Jun;68(6):1317-27. [4]. Badger AM, et al. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61. [5]. Lin Y, et al. Critical role of astrocytic interleukin-17?A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice. Cell Death Dis. 2016 Jun 23;7(6):e2273
Specification	10mg 20mg 50mg