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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > StaurosporineCAS：62996-74-1
Molecular Formula：C28H26N4O3
Molecular Weight：466.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 62996-74-1 |
| Name | Staurosporine |
| Molecular Formula | C28H26N4O3 |
| Molecular Weight | 466.53 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 613-127-7 |
| MDL | MFCD00077402 |
| SMILES | O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83 |
| InChIKey | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
| InChI | InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 |
| PubChem CID | 44259 |
| Target Point | PKC;PKA;c-Fgr;Phosphorylase kinase |
| Passage | TGF-beta/Smad;Epigenetics |
| Background | Staurosporine is a potent, non-selective protein kinase inhibitor. |
| Biological Activity | Staurosporine是一种有效，非选择性蛋白激酶抑制剂，抑制 PKC，PKA，c-Fgr，和 Phosphorylase kinase 的 IC50 分别为 6 nM，15 nM，2 nM，3 nM。[1-4] |
| IC50 | PKC:6nM;c-Fgr:2nM;Phosphorylase kinase:3nM;v-Src:6nM;cdc2:9nM;TPK-IIB/Syk:16nM;Ca2+/CaM PK-I1:20nM;S6 kinase(70 kDa):5nM;PKA:15nM [1-4] |
| Data Literature Source | [1]. Meggio F，et al. Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem. 1995 Nov 15;234(1):317-22. [2]. Chae HJ，et al. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol Res. 2000 Oct;42(4):373-81. [3]. Yoshizawa S，et al. Tumor-promoting activity of staurosporine，a protein kinase inhibitor on mouse skin.Cancer Res. 1990 Aug 15;50(16):4974-8. [4]. Nabeshima T，et al. Staurosporine facilitates recovery from the basal forebrain-lesion-induced impairment of learning and deficit of cholinergic neuron in rats. J Pharmacol Exp Ther. 1991 May;257(2):562-6. |
| Unit | Piece |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Alfhili MA, et. . Int J Occup Med Environ Health. 2022 Feb 15;35(1):1-11. doi: 10.13075/ijomeh.1896.01814.
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Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling.
Click to check >>Author：Alfhili MA, Alamri HS, Alsughayyir J, Basudan AM.
IF：1.6760
Publish_to：Int J Occup Med Environ Health.
PMID：34524276
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