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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > Bisindolylmaleimide ICAS：133052-90-1
Molecular Formula：C25H24N4O2
Molecular Weight：412.48
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Orange to red Solid
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| CAS | 133052-90-1 |
| Name | Bisindolylmaleimide I |
| Molecular Formula | C25H24N4O2 |
| Molecular Weight | 412.48 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Orange to red Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00236428 |
| SMILES | O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O |
| InChIKey | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| PubChem CID | 2396 |
| Target Point | PKC |
| Passage | TGF-beta/Smad;Epigenetics |
| Background | It is a highly selective and reversible PKC inhibitor. |
| Biological Activity | Bisindolylmaleimide I 是一种具有高度选择性, 细胞可渗透性和可逆性的 PKC抑制剂, Ki值为14 nM[1-2]。 |
| IC50 | Bovine brain PKC:10nM (IC50) PKCβII:16nM (IC50) PKCβI:17nM (IC50) PKCα:20nM (IC50) PKCγ:20nM (IC50) FDGFR:65μM (IC50) [1-2] |
| Data Literature Source | [1]. Toullec D， et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991 Aug 25; 266 (24) :15771-81. [2]. Vetri F， et al. Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor. Brain Res. 2017 Jan 15; 1655:48-54 |
| Unit | Piece |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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