English Name |
Anti-TTR Polyclonal Antibody |
Chinese Name |
甲状腺素转运蛋白抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:1000-3000. IHC 1:50-200. |
Target |
TTR |
Synonyms |
Transthyretin, Amyloid polyneuropathy, Amyloidosis I, ATTR, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, PALB, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TBPA, Transthyretin, TTR, TTR protein, prealbumin, TTHY_HUMAN |
Background |
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. |
Swiss Prot |
P02766 |
Gene ID |
7276 |
Subcellular Location |
Secreted |
Immunogen |
Recombinant protein of human TTR |
Public Immunogen Range |
1-147aa |
Calculated MW |
16kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Unit |
Piece |
Specification |
50ul 100ul |