English Name |
Anti-PRG2 Polyclonal Antibody |
Chinese Name |
嗜酸性粒细胞颗粒关键碱性蛋白抗体 |
Target |
PRG2 |
Synonym |
BMPG, EMBP, Eosinophil granule major basic protein, Major Basic Protein, Eosinophil major basic protein, MBP, MBP1, Natural killer cell activator, Pregnancy-associated major basic protein, PRG 2, PRG2, PRG2_HUMAN, Proteoglycan 2, Proteoglycan 2 bone marrow, Proteoglycan 2 preproprotein |
Backgroud |
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
P13727 |
Gene ID |
5553 |
Subcellular Localization |
Cytoplasmic vesicle Secreted Secretory vesicle |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
23/25kDa |
Dilution Ratio |
WB 1:500-1000. IHC 1:50-200. IF 1:50-200. |
Immunogen |
A synthetic peptide of human PRG2 |
Public Immunogen Range |
100-200aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC IF |
Specification |
50ul 100ul |