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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-NLRP3 Polyclonal Antibody
Chinese Name	细胞凋亡诱导蛋白NALP3抗体
Target	NLRP3
Synonym	NLRP3;AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;FCAS;FCAS1;FCU;MWS;NALP3;PYPAF1
Backgroud	This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Swiss Prot	Q96P20
Gene ID	114548
Subcellular Localization	Cytoplasm Endoplasmic reticulum Inflammasome Nucleus Secreted Cytosol
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Protein MW	83/105/111/112/115/118kDa
Dilution Ratio	WB 1:1000-5000. IF 1:50-200.
Immunogen	Recombinant protein of human NLRP3
Public Immunogen Range	100-210aa
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human Mouse Rat
Application	WB IF
Specification	50ul 100ul