{{cart_num}}
My CartCAS：890128-81-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 890128-81-1 |
| Name | BFH772 |
| Molecular Formula | C23H16F3N3O3 |
| Molecular Weight | 439.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30534392 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=CC(OC4=NC=NC(CO)=C4)=CC=C32 |
| Target Point | VEGFR2 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | BFH772 is a novel, potent, VEGFR2 inhibitor. |
| Biological Activity | BFH772是一种新型的、有效的、可口服的VEGFR2抑制剂，IC50为3 nM。[1] |
| In Vitro | BFH772有效地靶向VEGFR2，IC50为3 nM。而对FLK-1、FLT-1、FLT-4的有效性比对VEGFR2低500倍。除了VEGFR2，它还能靶向B-RAF，RET和TIE-2，尽管对它们的有效性比对VEGFR2低40倍以上。BFH772抑制配体所诱导的RET、PDGFR、KIT激酶的自磷酸化，IC50为30-160 nM[1]。 |
| In Vivo | 每天给以口服3 mg/kg的BFH772能有效地抑制黑色素瘤的生长(对原发性肿瘤来说，减少54-90%；对转移瘤来说，减少71-96%)[1]。 |
| Cell Experiment | Animal Models: Sprague Dawley大鼠; Dosages: 1 mg/kg; Administration: 静脉注射[1] |
| Animal Experiment | 将半融合状态的HUVECs接种于96孔板，用含1.5% FCS和固定浓度的VEGF(10 ng/mL)，bFGF(0.5 ng/mL)或bFGF(0.5 ng/mL)、及检测化合物的基础培养基进行培养。24小时后，加入BrdU标记溶液，再将细胞继续培养24小时，然后固定、封闭、加anti-BrdU抗体进行染色。[1] |
| Data Literature Source | [1] Bold G，et al. J Med Chem. 2016，59(1):132-46. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg |
BFH772是一种新型的、有效的、VEGFR2抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
