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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > R406CAS：841290-81-1
Molecular Formula：C28H29FN6O8S
Molecular Weight：628.63
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥96%
Appearance：Light yellow to brown Solid
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| CAS | 841290-81-1 |
| Name | R406 |
| Molecular Formula | C28H29FN6O8S |
| Molecular Weight | 628.63 |
| Solubility | Soluble in DMSO |
| Purity | ≥96% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18385012 |
| SMILES | COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC.OS(C5=CC=CC=C5)(=O)=O |
| Target Point | FLT3;Syk |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | R406 is an ATP-competitive Syk inhibitor. |
| Biological Activity | R406 是一种ATP竞争性的 Syk 抑制剂，Ki 为 30 nM，有效抑制 Syk 激酶活性，IC50 为 41 nM。[1-3] |
| IC50 | 41nM(Syk)[1] |
| Data Literature Source | [1]. Braselmann S，et al. R406，an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther，2006，319(3)，998-1008. [2]. Hatton O，et al. Syk-induced phosphatidylinositol-3-kinase activation in Epstein-Barr virus posttransplant lymphoproliferative disorder. Am J Transplant. 2013 Apr;13(4):883-90. [3]. Kitai M，et al. Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice. J Pharmacol Sci. 2017 May;134(1):29-36. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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