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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > GNF-5CAS：778277-15-9
Molecular Formula：C20H17F3N4O3
Molecular Weight：418.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 778277-15-9 |
| Name | GNF-5 |
| Molecular Formula | C20H17F3N4O3 |
| Molecular Weight | 418.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD16877246 |
| SMILES | FC(F)(F)OC(C=C1)=CC=C1NC2=NC=NC(C3=CC=CC(C(NCCO)=O)=C3)=C2 |
| Target Point | Bcr-Abl |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | GNF-5, an analog of GNF-2, is a non-ATP-competitive inhibitor of Bcr-Abl. |
| Biological Activity | GNF-5， the N-hydroxyethyl carboxamide analog of GNF-2， is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 μM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer[1][2]. |
| IC50 | IC50: 0.22 μM (Abl)[1] |
| Data Literature Source | [1]. Zhang J，et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28;463(7280):501-6. [2]. Meirson T，et al. Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. Oncotarget. 2018 Apr 24;9(31):22158-22183. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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