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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > GNF-2CAS：778270-11-4
Molecular Formula：C18H13F3N4O2
Molecular Weight：374.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 778270-11-4 |
| Name | GNF-2 |
| Molecular Formula | C18H13F3N4O2 |
| Molecular Weight | 374.32 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD09265253 |
| SMILES | O=C(C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1)N |
| Target Point | Bcr-Abl |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | GNF-2 is a non-ATP-competitive Bcr-Abl selective inhibitor. |
| Biological Activity | GNF-2 is a highly selective， allosteric， non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM [1]. |
| IC50 | Bcr-Abl |
| Data Literature Source | [1]. Adrián FJ，et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006 Feb;2(2):95-102. [2]. Kim HJ，et al. The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity. J Leukoc Biol. 2013 Oct 15. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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