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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > SpebrutinibCAS：1202757-89-8
Molecular Formula：C22H22FN5O3
Molecular Weight：423.44
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 1202757-89-8 |
| Name | Spebrutinib |
| Molecular Formula | C22H22FN5O3 |
| Molecular Weight | 423.44 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25976876 |
| SMILES | COCCOC1=CC=C(NC2=NC=C(F)C(NC3=CC=CC(NC(C=C)=O)=C3)=N2)C=C1 |
| Target Point | Btk |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | Spebrutinib is a highly selective Btk inhibitor. |
| Biological Activity | Spebrutinib 是共价，高选择性和口服活性的 Btk 抑制剂，IC50 为0.5 nM。[1] |
| Data Literature Source | [1]. Evans EK，et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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