English Name |
Anti-IFITM3 Polyclonal Antibody |
Chinese Name |
干扰素诱导跨膜蛋白3抗体 |
Target |
IFITM3 |
Synonym |
1 8U, Ifitm 3, IFITM3, IFM3_HUMAN, Interferon induced transmembrane protein 3 (1 8U), Interferon Induced Transmembrane Protein 3, Interferon inducible, Interferon inducible protein 1 8U, Interferon Inducible Protein 15, Interferon Inducible Protein Homolog, Interferon-induced transmembrane protein 3, Interferon-inducible protein 1-8U, IP15 |
Backgroud |
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. |
Swiss Prot |
Q01628 |
Gene ID |
10410 |
Subcellular Localization |
Cytoplasm |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
14kDa |
Dilution Ratio |
IHC 1:50-200. |
Immunogen |
A synthetic peptide of Human IFITM3 |
Public Immunogen Range |
1-51/133aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human |
Application |
IHC |
Specification |
50ul 100ul |