English Name |
Anti-HER2 Polyclonal Antibody |
Chinese Name |
HER2受体抗体 |
Target |
HER2 |
Synonym |
CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 |
Backgroud |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
Swiss Prot |
P04626 |
Gene ID |
2064 |
Subcellular Localization |
Cell membrane Cytoplasm Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
135kDa |
Dilution Ratio |
ELISA 1:5000-10000. IHC 1:100-500. IF 1:100-500. |
Immunogen |
A synthetic peptide of human HER2 |
Public Immunogen Range |
1201-1255/1255aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human |
Application |
IHC IF ELISA |
Specification |
50ul 100ul |