Anti-NTRK2 Polyclonal Antibody
Cat.No:K009459P Solarbio
Reactivity:Rat,Human
Application:WB,ELISA,FCM,IF,IHC
Clone Type:Polyclonal Antibody
Storage:Store at -20℃. Avoid freeze / thaw cycles.
Gene ID:4915
Host:Rabbit
Qty:
Size:
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My CartReactivity:Rat,Human
Application:WB,ELISA,FCM,IF,IHC
Clone Type:Polyclonal Antibody
Storage:Store at -20℃. Avoid freeze / thaw cycles.
Gene ID:4915
Host:Rabbit
Qty:
Size:
Name | Anti-NTRK2 Polyclonal Antibody |
Host | Rabbit |
Clone Type | Polyclonal Antibody |
Subtype | IgG |
Predicted Reactivity | Mouse |
Dilution Ratio | WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test. IF 1:100-500. |
Target | NTRK2 |
Background | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. |
Swiss Prot | Q16620 |
Gene ID | 4915 |
Subcellular Location | Cell membrane Endosome membrane Single-pass type I membrane protein |
Immunogen | A synthetic peptide of human NTRK2 |
Public Immunogen Range | 401-500/822aa |
Calculated MW | 35/53/59/60/81/91/93kDa |
Purification Method | Affinity purification |
Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA,0.03% Proclin300 and 50% Glycerol. |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Unit | Piece |
Specification | 50ul 100ul |
Reactivity | Rat Human |
Application | ELISA FCM IF IHC WB |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder:Quick spin before use. If you have any questions, please contact us.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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