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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-SOCS7 Polyclonal Antibody
Chinese Name	信号转导和转录激活因子7抗体
Target	SOCS7
Synonym	NAP 4;NAP 4 Fragment;NAP4;Nck Ash and phospholipase C binding protein;Nck Ash and phospholipase C gamma binding protein;Nck associated protein 4;NCKAP4;SH2 domain containing SOCS box protein;SOCS 7;SOCS4;SOCS6;Suppressor of cytokine signaling 7
Backgroud	Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Swiss Prot	O14512
Gene ID	30837
Subcellular Localization	Cell membrane Cytoplasm
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Predicted Cross-Reactivity	Rabbit
Protein MW	63kDa
Dilution Ratio	WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. ICC 1:100-500. IF 1:100-500.
Immunogen	A synthetic peptide of human SOCS7
Public Immunogen Range	171-270/581aa
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human Mouse Rat
Application	WB IHC ICC IF ELISA
Specification	50ul 100ul