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My Cart> Antibodies > Primary Antibodies > Anti-phospho-PKM(Tyr105) Polyclonal AntibodyReactivity：Rat,Human
Application：IHC,ELISA,FCM,IF
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：5315
Host：Rabbit
Qty：
Size：
| Name | Anti-phospho-PKM(Tyr105) Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Mouse;Dog;Pig;Cow;Horse;Rabbit;Guinea Pig |
| Dilution Ratio | ELISA 1:5000-10000. IHC 1:100-500. FCM 1ug/Test. IF 1:100-500. |
| Target | phospho-PKM(Tyr105) |
| Background | Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. |
| Swiss Prot | P14618 |
| Gene ID | 5315 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | A synthetic peptide of human PKM2 around the phosphorylation site of Tyr105 |
| Calculated MW | 58kDa |
| Purification Method | Affinity purification |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Specification | 50ul 100ul |
| Reactivity | Rat Human |
| Application | ELISA FCM IF IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Immunohistochemistry of paraffin-embedded Human liver carcinoma with phospho-PKM(Tyr105) antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded human endometrium tissue with Phospho-PKM2 (Tyr105) antibody diluted at 1:200.
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