English Name |
Anti-IGF1R Polyclonal Antibody |
Chinese Name |
胰岛素样蛋白生长因子1受体抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Predicted Reactivity |
Rat;Pig;Cow;Sheep |
Dilution Ratio |
WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test. ICC 1:100. IF 1:100-500. |
Target |
IGF1R |
Synonyms |
CD221,CD221 antigen,IGF1 Receptor,IGF 1 receptor,IGF 1R,IGF I receptor,IGF1R,IGFIR,IGFIRC, JTK13,MGC142170,MGC142172,IGF 1 receptor,IGF-1R,IGF I receptor,IGF-I receptor,IGF-IR,IGF-I Receptor β |
Background |
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
Swiss Prot |
P08069 |
Gene ID |
3480 |
Subcellular Location |
Cell membrane |
Immunogen |
A synthetic peptide of human IGF1R |
Public Immunogen Range |
821-920/1367aa |
Calculated MW |
69/150kDa |
Purification Method |
Affinity purification |
Storage Buffer |
0.01M TBS(pH7.4) with 1% BSA,0.03% Proclin300 and 50% Glycerol. |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Unit |
Piece |
Specification |
50ul 100ul |