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My CartReactivity：Mouse,Rat,Human,Monkey
Application：IF,IHC,WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：4478
Host：Rabbit
Qty：
Size：
| Name | Anti-MSN Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:8000-12000. IHC 1:100-300. IF 1:50-200. |
| Target | MSN |
| Background | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation. |
| Swiss Prot | P26038 |
| Gene ID | 4478 |
| Subcellular Location | Cytoplasm |
| Immunogen | A synthetic peptide of human MSN |
| Public Immunogen Range | 455-505/577aa |
| Calculated MW | 68kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Monkey Rat Mouse |
| Application | WB IF IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with MSN antibody diluted at 1:8000;Lane: Jurkat,Hela,HMC1,A431,HEK293,Vero,HT29,Raji,NIH3T3,SH-SY5Y,Mouse thymus,Mouse kidney.
Immunohistochemistry of paraffin-embedded Human breast cancer with MSN antibody diluted at 1:200.
Immunofluorescence analysis of HepG2 cells using MSN antibody diluted at 1:100.
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