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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > ER Stress > GSK2606414CAS：1337531-36-8
Molecular Formula：C24H20F3N5O
Molecular Weight：451.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1337531-36-8 |
| Name | GSK2606414 |
| Molecular Formula | C24H20F3N5O |
| Molecular Weight | 451.44 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25976926 |
| SMILES | NC1=C2C(N(C)C=C2C3=CC4=C(N(C(CC5=CC=CC(C(F)(F)F)=C5)=O)CC4)C=C3)=NC=N1 |
| Target Point | PERK |
| Passage | ER Stress;Cell Cycle |
| Background | GSK2606414 is a PERK inhibitor. |
| Biological Activity | GSK2606414是可渗透细胞且可口服的 PERK 抑制剂，IC50值为0.4 nM[1-2]。 |
| IC50 | EIF2AK3(PERK):0.4nM(IC50);EIF2AK1(HRI):420nM(IC50);EIF2AK2(PKR):696nM(IC50)[1-2] |
| Data Literature Source | [1]. Axten JM，et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2，3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2，3-d]pyrimidin-4-amine (GSK2606414)，a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulu [2]. Zhang M，et al. Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency. Cell Host Microbe. 2017 Dec 13;22(6):766-776.e4. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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