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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > LCL-161CAS：1005342-46-0
Molecular Formula：C26H33FN4O3S
Molecular Weight：500.63
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1005342-46-0 |
| Name | LCL-161 |
| Molecular Formula | C26H33FN4O3S |
| Molecular Weight | 500.63 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23160049 |
| SMILES | C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O |
| Target Point | IAP |
| Passage | Apoptosis |
| Background | LCL161 is an inhibitor of IAP. |
| Biological Activity | LCL161是 IAP 的抑制剂，抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1 的 IC50 分别为 35 和 0.4 nM。[1-4] |
| IC50 | 35nM(XIAP，in HEK293 cell)，0.40nM(cIAP1，inmDA-MB-231)[1] |
| Data Literature Source | [1]. Maria Ahn，et al. Potent，Dual cIAP1/XIAP Antagonists Induce Apoptosis in a Melanoma Stem Cell Population [2]. Chen KF，et al. Inhibition of Bcl-2 improves effect of LCL161，a SMAC mimetic，in hepatocellular carcinoma cells. Biochem Pharmacol. 2012 Aug 1;84(3):268-77. [3]. Dhuria S，et al. Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist，LCL161，in vitro and in vivo in healthy subjects. J Clin Pharmacol. 2013 Jun;53(6):642-53. [4]. Infante JR，et al. Phase I dose-escalation study of LCL161，an oral inhibitor of apoptosis proteins inhibitor，in patients with advanced solid tumors. J Clin Oncol. 2014 Oct 1;32(28):3103-10. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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