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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Tenovin-6 HydrochlorideCAS：1011301-29-3
Molecular Formula：C25H35ClN4O2S
Molecular Weight：491.09
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1011301-29-3 |
| Name | Tenovin-6 Hydrochloride |
| Molecular Formula | C25H35ClN4O2S |
| Molecular Weight | 491.09 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2.Cl |
| Target Point | Sirtuin |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | Tenovin-6 is an analog of Tenovin-1 that inhibits the protein deacetylase activities of SIRT1, SIRT2 and SIRT3 |
| Biological Activity | Tenovin-6 Hydrochloride， an analog of Tenovin-1， is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1， SIRT2， and SIRT3 with IC50s of 21 μM， 10 μM， and 67 μM， respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH)[1-2]. |
| Data Literature Source | [1]. Lain S，et al. Discovery，in vivo activity，and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. [2]. Ladds MJGW，et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print，2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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