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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > LRRK2-IN-1CAS：1234480-84-2
Molecular Formula：C31H38N8O3
Molecular Weight：570.69
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1234480-84-2 |
| Name | LRRK2-IN-1 |
| Molecular Formula | C31H38N8O3 |
| Molecular Weight | 570.69 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22683805 |
| SMILES | O=C(C1=CC(OC)=C(NC2=NC=C3C(N(C4=C(C(N3C)=O)C=CC=C4)C)=N2)C=C1)N5CCC(CC5)N6CCN(CC6)C |
| Target Point | LRRK2 |
| Passage | Autophagy |
| Background | LRRK2-IN-1 is a potent and selective LRRK2 inhibitor. |
| Biological Activity | LRRK2-IN-1 是一种有效的, 选择性的 LRRK2 抑制剂, 作用于 LRRK2 (G2019S) 和 LRRK2 (WT) , IC50 值分别为 6 nM 和 13 nM[1-4]。 |
| IC50 | IC50: 13nM (WT) ， 6nM (G2019S) [1-4] |
| Data Literature Source | [1]. Hermanson SB， et al. Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation.PLoS One. 2012; 7 (8) :e43580. Epub 2012 Aug 28. [2]. Deng， Xianming.， et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology (2011) ， 7 (4) ， 203-205. [3]. Koshibu K， et al. Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease. Pharmacology. 2015; 96 (5-6) :240-7. [4]. Weygant N， et al. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 6; 13:103 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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