{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PF-477736CAS：952021-60-2
Molecular Formula：C22H25N7O2
Molecular Weight：419.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
Qty：
Size：
| CAS | 952021-60-2 |
| Name | PF-477736 |
| Molecular Formula | C22H25N7O2 |
| Molecular Weight | 419.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038847 |
| SMILES | O=C([C@@H](C1CCCCC1)N)NC2=CC3=C(C(C=NNC4=O)=C(N3)C5=CN(N=C5)C)C4=C2 |
| Target Point | YES;VEGFR2;Checkpoint Kinase (Chk);Fms |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK;Cell Cycle |
| Background | PF 477736 is a potent, ATP-competitive inhibitor of Chk1. |
| Biological Activity | PF 477736 是一种有效的，ATP 竞争性的 Chk1 抑制剂，Ki 为 0.49 nM，对其选择性是 Chk2 (Ki, 47 nM) 的 100 倍。[1-2] |
| Data Literature Source | [1]. Blasina A，et al. Breaching the DNA damage checkpoint via PF-00477736，a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther. 2008 Aug;7(8):2394-404 [2]. Ashwell S，et al. Keeping checkpoint kinases in line: new selective inhibitors in clinical trials. Expert Opin Investig Drugs. 2008 Sep;17(9):1331-40. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
