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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > CHIR-124CAS：405168-58-3
Molecular Formula：C23H22ClN5O
Molecular Weight：419.91
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 405168-58-3 |
| Name | CHIR-124 |
| Molecular Formula | C23H22ClN5O |
| Molecular Weight | 419.91 |
| Solubility | Soluble in DMSO ≥0.5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:-20℃，2 years |
| MDL | MFCD14636453 |
| SMILES | ClC1=CC2=C(NC(C(C3=NC4=C(C=CC=C4)N3)=C2N[C@@H]5CN6CCC5CC6)=O)C=C1 |
| Target Point | FLT3;PDGFR;Checkpoint Kinase (Chk);GSK-3 |
| Passage | Cell Cycle |
| Background | CHIR-124 is a potent and selective inhibitor of Chk1; it also potently inhibits PDGFR and FLT3. |
| Biological Activity | CHIR-124 是一种有效的，选择性的 Chk1 抑制剂，IC50 值为 0.3 nM；同时可有效抑制 PDGFR 和 FLT3，IC50 值分别为 6.6 nM 和 5.8 nM[1-2]。 |
| Data Literature Source | [1]. Tse AN，et al. CHIR-124，a novel potent inhibitor of Chk1，potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res，2007，13(2 Pt 1)，591-602. [2]. Dai Y，et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res，2010，16(2)，376-383. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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