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Application：ELISA
Reactivity：Human
Sample Type：Serum，Plasma，Cell Culture Supernatant
Sensitivity：22pg/mL
Storage：2-8℃，6 months
Gene ID：2263
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Size：
| Name | Human FGFR2 ELISA Kit |
| Storage | 2-8℃，6 months |
| Detection Target | FGFR2/CD332 |
| Sample Type | Serum，Plasma，Cell Culture Supernatant |
| Reactivity | Human |
| Application | ELISA |
| Quantitative/Qualitative | Quantitative |
| Detection Range | 43.75-2800pg/mL |
| Sensitivity | 22pg/mL |
| Precision | Both intra-plate and inter-plate variation coefficients were less than 10% |
| Recovery | 80%-120% |
| Swiss Prot | P21802 |
| Gene ID | 2263 |
| Background | FGFR2，also known as CD332，belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation，differentiation，migration and apoptosis，and in the regulation of embryonic development. It is required for normal embryonic patterning，trophoblast function，limb bud development，lung morphogenesis，osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation，proliferation and apoptosis，and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts，but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination，internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation，internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome，Jackson-Weiss syndrome，Apert syndrome，Pfeiffer syndrome，Beare-Stevenson cutis gyrata syndrome，familial scaphocephaly syndrome，lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis. |
| Unit | Kit |
| Specification | 48T 96T |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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