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AGK-2

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Cat.No：IA4250 Solarbio

CAS：304896-28-4

Molecular Formula：C₂₃H₁₃Cl₂N₃O₂

Molecular Weight：434.27

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	304896-28-4
Name	AGK-2
Molecular Formula	C₂₃H₁₃Cl₂N₃O₂
Molecular Weight	434.27
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD01909444
SMILES	O=C(NC1=C2C=CC=NC2=CC=C1)/C(C#N)=C/C3=CC=C(C4=CC(Cl)=CC=C4Cl)O3
Target Point	Sirtuin（SIRT1）
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	AGK2 is a potent and selective SIRT2 inhibitor.
Biological Activity	AGK2 是一个选择性 SIRT2 抑制剂，其 IC50 值为 3.5 μM。AGK2 也可以抑制 SIRT1 和 SIRT3，且IC50 值分别为 30 和 91 μM[1-4]。
IC50	SIRT2:3.5μM;SIRT1:30μM;SIRT3:91μM [1-4]
Data Literature Source	[1]. Tatum PR，et al. Identification of novel SIRT2-selective inhibitors using a click chemistry approach. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1871-4. [2]. Kim HW，et al. Sirtuin inhibitors，EX527 and AGK2，suppress cell migration by inhibiting HSF1 protein stability. Oncol Rep. 2016 Jan;35(1):235-42. [3]. Li Y，et al. Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. Neurosci Lett. 2013 Jun 7;544:36-40. [4]. Zhao T，et al. Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model. Curr Mol Med. 2015;15(7):634-41.
Unit	Bottle
Specification	2mg 5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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