CAS:841301-32-4
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
是一种helicase-primase抑制剂,对HSV具有强抗病毒活性
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AmenamevirCAS:841301-32-4
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 841301-32-4 |
Chinese Name | 阿莫奈韦 |
English Name | Amenamevir |
Synonyms | ASP2151 |
Molecular Formula | C24H26N4O5S |
Molecular Weight | 482.55 |
Solubility | Soluble in DMSO ≥5mg/mL |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD19443709 |
SMILES | O=C(C(CC1)CCS1(=O)=O)N(C2=C(C)C=CC=C2C)CC(NC3=CC=C(C4=NOC=N4)C=C3)=O |
Target Point | DNA/RNA Synthesis inhibitor |
Passage | Cell Cycle;DNA Damage/DNA Repair |
Background | Amenamevir is an HSV (herpes simplex virus) helicase-primase inhibitor with potent antiviral activity against HSV |
Biological Activity | Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.[1] |
In Vitro | ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14(range,7.7 to 20)and 30 ng/ml(range,15 to 58),respectively[2]. |
In Vivo | In the cutaneously HSV-1-infected mouse model,ASP2151 dose dependently suppressed intradermal HSV-1 growth,with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2]. |
Cell Experiment | Animal Models: HSV-1-infected mice; Dosages: 1,3,10,30,or 100 mg/kg/day; Administration: oral[2] |
Data Literature Source | [1] Kawashima M,et al. J Dermatol. 2017,44(11):1219-1227. [2] Katsumata K,et al. Antimicrob Agents Chemother. 2013,57(3):1339-46. |
Unit | Bottle |
Specification | 5mg |
是一种helicase-primase抑制剂,对HSV具有强抗病毒活性