CAS |
69-74-9 |
Chinese Name |
盐酸阿糖胞苷 |
English Name |
Cytarabine Hydrochloride |
Synonym |
Cytosine β-D-arabinofuranoside hydrochloride;Cytosine Arabinoside hydrochloride;Ara-C hydrochloride |
Unit |
Bottle |
Purity |
≥97% |
Molecular Formula |
C9H13N3O5·HCl |
Molecular Weight |
279.68 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO |
MDL |
MFCD00012839 |
EC |
EINECS 200-713-9 |
InChIKey |
KCURWTAZOZXKSJ-JBMRGDGGSA-N |
InChI |
InChI=1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1 |
PubChem CID |
6252 |
SMILES |
O=C1N=C(N)C=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O.Cl |
Description |
Cytarabine Hydrochloride has anti-metabolic and anti-DNA synthesis activity. |
Target Point |
DNA/RNA Synthesis |
Passage |
Cell Cycle;DNA Damage/DNA Repair |
Data Literature Source |
[1]. Tobias, S.C. and R.F. Borch, Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm, 2004. 1(2): p. 112-6.
[2]. Besirli, C.G., et al. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ, 2003. 10(9): p. 1045-58.
[3]. Yamauchi, H., et al., Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Biol Reprod, 2004. 70(6): p. 1762-7.
[4]. Richel, D.J., et al., Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia. Br J Cancer, 1988. 58(6): p. 730-3 |
Specification |
100mg 10mM*1mL in DMSO 500mg |