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Midostaurin

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Cat.No：IM2560 Solarbio

CAS：120685-11-2

Molecular Formula：C₃₅H₃₀N₄O₄

Molecular Weight：570.64

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	120685-11-2
Name	Midostaurin
Molecular Formula	C₃₅H₃₀N₄O₄
Molecular Weight	570.64
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00871372
SMILES	O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Target Point	PKC;Syk;Flk-1;Akt;PKA;c-Kit
Passage	TGF-beta/Smad;Epigenetics
Background	Midostaurin is a multi-target kinase inhibitor that inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ, and VEGFR1/2.
Data Literature Source	[1]. Fabbro D，et al. PKC412--a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 2000 Feb;15(1):17-28. [2]. Fabbro D，et al. Inhibitors of protein kinases: CGP 41251，a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82(2-3):293-301. [3]. Huige Li，et al. Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse. Nitric Oxide. 2005 Jun;12(4):231-6. [4]. Gleixner KV，et al. Synergistic growth-inhibitory effects of Midostaurin (PKC412) on neoplastic mast cells carrying KIT D816V. Haematologica. 2013 Sep;98(9):1450-7.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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