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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PF-3758309CAS：898044-15-0
Molecular Formula：C25H30N8OS
Molecular Weight：490.62
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 898044-15-0 |
| Name | PF-3758309 |
| Molecular Formula | C25H30N8OS |
| Molecular Weight | 490.62 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18633226 |
| SMILES | CC1=NC2=C(SC=C2)C(NC3=NNC4=C3CN(C(N[C@@H](C5=CC=CC=C5)CN(C)C)=O)C4(C)C)=N1 |
| Target Point | PAK |
| Passage | Cell Cycle; Cytoskeleton |
| Background | PF-3758309 is a bioavailable, ATP-competitive p21-activated kinase (PAK) inhibitor. |
| Biological Activity | PF-3758309 是一种有效的 PAK 抑制剂，能够抑制 PAK4 的活性，IC50 值为 1.3 nM[1-4]。 |
| Data Literature Source | [1]. Murray，Brion W.，et al. Small-molecule p21-activated kinase inhibitor PF3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proceedings of the National Academy of Sciences of the United States of America (2010)，107(20)，9446-9451，S94 [2]. Zhao ZS，et al. Do PAKs make good drug targets F1000 Biol Rep. 2010 Sep 23;2:70. [3]. Ryu BJ，et al. PF-3758309，p21-activated kinase 4 inhibitor，suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB，NF-κB，and β-catenin signalings. Mol Cell Biochem. 2014 Apr;389(1-2):69-77. [4]. Pitts TM，et al. Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor，PF-3758309，in colon cancer models. Front Pharmacol. 2013 Mar 28;4:35. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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