{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > XL-413CAS：1169562-71-3
Molecular Formula：C14H12ClN3O2·HCl
Molecular Weight：326.18
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1169562-71-3 |
| Name | XL-413 |
| Molecular Formula | C14H12ClN3O2·HCl |
| Molecular Weight | 326.18 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00060671 |
| SMILES | ClC1=CC=C2C(C(N=C([C@@H]3CCCN3)NC4=O)=C4O2)=C1.[H]Cl.[x] |
| Target Point | CK2;CDK;Cdc7;Pim1 |
| Passage | Cell Cycle;DNA Damage/DNA Repair; JAK/STAT Signaling |
| Background | XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor. |
| Biological Activity | XL413 hydrochloride 是一种有效的，选择性的，ATP 竞争性的 Cdc7 抑制剂，IC50 值为 3.4 nM，同时对 CK2 和 PIM1 的 IC50 值分别为 215 和 42 nM，对 pMCM 的 EC50 值为 118 nM。[1-2] |
| Data Literature Source | [1]. Koltun ES，et al. Discovery of XL413，a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. [2]. Sasi NK，et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
