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XL-888

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Cat.No：IX0110 Solarbio

CAS：1149705-71-4

Molecular Formula：C₂₉H₃₇N₅O₃

Molecular Weight：503.64

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	1149705-71-4
Name	XL-888
Molecular Formula	C₂₉H₃₇N₅O₃
Molecular Weight	503.64
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD22124888
SMILES	CC1=CC(C(N)=O)=C(N[C@H](C)CC)C=C1C(N[C@]2([H])C[C@H](CC3)N(C4=NC=C(C(C5CC5)=O)C=C4)[C@H]3C2)=O
Target Point	HSP
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	XL888, an ATP-competitive inhibitor of HSP90
Biological Activity	XL888 是一种热休克蛋白 90 (HSP90) 抑制剂，IC50 值为 24 nM。[1-3]
Data Literature Source	[1]. Haarberg HE，et al. Inhibition of Wee1，AKT，and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. Mol Cancer Ther. 2013 Jun;12(6):901-12. [2]. Paraiso KH，et al. The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms. Clin Cancer Res. 2012 May 1;18(9):2502-14. [3]. Bussenius J，et al. Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5396-404.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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