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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > 5-MethoxyflavoneCAS：42079-78-7
Molecular Formula：C16H12O3
Molecular Weight：252.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 42079-78-7 |
| Name | 5-Methoxyflavone |
| Molecular Formula | C16H12O3 |
| Molecular Weight | 252.27 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 255-652-0 |
| MDL | MFCD00016942 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=CC=CC(OC)=C13 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | 5-Methoxyflavone, a flavonoid, is a DNA polymerase-beta (DNA polymerase-beta) inhibitor and a neuroprotectant against beta-amyloid toxicity. |
| Biological Activity | 5-Methoxyflavone，是一种类黄酮，是DNA polymerase-beta的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。拥有中枢神经系统镇静剂的作用,通过调控嗜离子 GABAA 受体来实现。[1-3] |
| Data Literature Source | [1]. Merlo S， et al. Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity. J Nat Prod. 2015 Nov 25; 78 (11) :2704-11. [2]. Shanmugasundaram J， et al. Sedative-hypnotic like effect of 5-methoxyflavone in mice and investigation on possible mechanisms by in vivo and in silico methods. Biomed Pharmacother. 2018 Dec; 108:85-94. [3]. Wudtiwai B， et al. Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. J Hematol Oncol. 2011 Dec 21; 4:52. |
| Unit | Bottle |
| Specification | 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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