CAS |
23541-50-6 |
Chinese Name |
盐酸柔红霉素 |
English Name |
Daunorubicin Hydrochloride |
Synonym |
盐酸柔红霉素;柔红霉素盐酸盐;道诺霉素盐酸盐;盐酸佐柔比星;红比霉素盐酸盐; |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C27H29NO10·HCl |
Molecular Weight |
563.98 |
Appearance |
Red solid |
Storage |
Powder : 2-8℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in water/DMSO≥10mg/ml |
EC |
EINECS 245-723-4 |
MDL |
MFCD04974507 |
InChIKey |
GUGHGUXZJWAIAS-QQYBVWGSSA-N |
InChI |
InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1 |
PubChem CID |
62770 |
SMILES |
O=C(C(C(OC)=CC=C1)=C1C2=O)C3=C2C(O)=C(C[C@@](O)(C(C)=O)C[C@@H]4O[C@@]5([H])C[C@H](N)[C@H](O)[C@H](C)O5)C4=C3O.[H]Cl |
Description |
Daunorubicin Hydrochloride is an antibiotic that inhibits DNA and RNA synthesis. It is also an inhibitor of topoisomerase II and can induce apoptosis. |
Target Point |
Antibiotic;Topoisomerase |
Passage |
Anti-infection;DNA Damage/DNA Repair |
Data Literature Source |
[1]. Lehmann M, et al. Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila Somatic Mutation and Recombination Test. Environ Mol Mutagen. 2004;43(4):250-7.
[2]. Svensson SP, et al. Melanin inhibits cytotoxic effects of Doxorubicin and Daunorubicin in MOLT 4 cells. Pigment Cell Res. 2003 Aug;16(4):351-4
[3]. Gervasoni JE Jr, et al. An effective in vitro antitumor response against human pancreatic carcinoma with paclitaxel and Daunorubicin by induction of both necrosis and apoptosis. Anticancer Res. 2004 Sep-Oct;24(5A):2617-26
[4]. Arozal W, et al. Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions. Toxicology. 2011 Jan 11;279(1-3):91-9 |
Specification |
5mg 10mM*1mL in Water 10mM*1mL in DMSO 10mg 20mg 50mg |