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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > LMK-235CAS：1418033-25-6
Molecular Formula：C15H22N2O4
Molecular Weight：294.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1418033-25-6 |
| Name | LMK-235 |
| Molecular Formula | C15H22N2O4 |
| Molecular Weight | 294.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 808-770-7 |
| MDL | MFCD26522892 |
| SMILES | O=C(NOCCCCCC(NO)=O)C1=CC(C)=CC(C)=C1 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | LMK-235 is a selective inhibitor of HDAC4 and HDAC5. |
| Biological Activity | LMK-235 是一种有效的，选择性的 HDAC4/5 抑制剂，可抑制 HDAC5，HDAC4，HDAC6，HDAC1，HDAC2，HDAC11 和 HDAC8 的活性，IC50 值分别为 4.22 nM，11.9 nM，55.7 nM，320 nM，881 nM，852 nM 和 1278 nM，可用于癌症研究。[1-3] |
| IC50 | HDAC5:4.22nM;HDAC4:11.9nM [1-3] |
| Data Literature Source | [1]. Marek L，et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 2013 Jan 24;56(2):427-36. [2]. Li A，et al. HDAC5，a potential therapeutic target and prognostic biomarker，promotes proliferation，invasion and migration in human breast cancer. Oncotarget. 2016 Jun 21;7(25):37966-37978. [3]. Trazzi S，et al. HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder. Hum Mol Genet. 2016 Sep 15;25(18):3887-3907. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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