| CAS |
5534/9/8 |
| Chinese Name |
丙酸倍氯米松 |
| English Name |
Beclomethasone Dipropionate |
| Synonyms |
二丙酸倍氯米松 |
| Molecular Formula |
C28H37ClO7 |
| Molecular Weight |
521.04 |
| Solubility |
Soluble in DMSO |
| Purity |
≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 226-886-0 |
| MDL |
MFCD00135613 |
| SMILES |
CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)C3(Cl)[C@@H](O)C[C@]12C)=O)=O |
| InChIKey |
KUVIULQEHSCUHY-XYWKZLDCSA-N |
| InChI |
InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1 |
| PubChem CID |
21700 |
| Target Point |
Glucocorticoid Receptor |
| Passage |
GPCR & G Protein |
| Background |
Beclomethasone dipropionate is a potent glucocorticoid |
| Biological Activity |
Betamethasone dipropionate, the prodrug of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1-2]. |
| In Vitro |
The Calcipotriol/Betamethasone combination significantly inhibits the secretion of IL-17A and TNF-α in psoriatic skin. Additionally，the two components show additive inhibitory effects on secretion of IL-23 and TNF-α by DCs，of IL-17A and TNF-α by both CD4+ and CD8+ T cells and reduced inflammatory responses in Th17-stimulated keratinocytes[1]. |
| In Vivo |
Betamethasone(5 mg/kg，orally)reduces the LPS-induced pulmonary inflammation and production of MMPs. Significantly(P < 0.05)inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.Markedly reduced the release of both MMP-2 and MMP-9.[2]. |
| Cell Experiment |
Animal Model: Ten-week-old male Balb/c mice; Dosage: 5 mg/kg(100 μg/ml for 60 min).; Administration: Orally at 24 h and 1 h before the LPS aerosol.[2] |
| Data Literature Source |
[1]. Paola Lovato，et al. Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J Dermatol Sci. 2016 Mar;81(3):153-64.
[2]. M Corbel，et al. Comparative effects of betamethasone，cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. Pulm Pharmacol Ther. 1999;12(3):165-71. |
| Unit |
Bottle |
| Specification |
250mg |
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