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Resminostat

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Cat.No：IR0780 Solarbio

CAS：864814-88-0

Molecular Formula：C₁₆H₁₉N₃O₄S

Molecular Weight：349.41

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	864814-88-0
Name	Resminostat
Molecular Formula	C₁₆H₁₉N₃O₄S
Molecular Weight	349.41
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1
Target Point	HDAC1，3，6
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Resminostat dose-dependently and selectively inhibits HDAC1/3/6.
Biological Activity	'Resminostat 是一种有效的 HDAC1, HHDAC3 和 HDAC6 抑制剂, IC50 值分别为 42.5, 50.1, 71.8 nM, 同时对 HDAC8 有较弱的抑制作用, IC50 值为 877 nM[1-3]。
IC50	HDAC1:42.5nM (IC50) HDAC3:50.1nM (IC50) HDAC6:71.8nM (IC50) HDAC8:877nM (IC50) [1-3]
Data Literature Source	[1]. Mandl-Weber S， et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol. 2010 May; 149 (4) :518-28. [2]. Enzenhofer E， et al. Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines. Head Neck. 2017 May; 39 (5) :900-907. [3]. Peng X， et al. mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat. Biochem Biophys Res Commun. 2016 Sep 2; 477 (4) :556-562.
Unit	Bottle
Specification	10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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