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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SirtinolCAS：410536-97-9
Molecular Formula：C26H22N2O2
Molecular Weight：394.47
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 410536-97-9 |
| Name | Sirtinol |
| Molecular Formula | C26H22N2O2 |
| Molecular Weight | 394.47 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00810186 |
| SMILES | O=C(NC(C1=CC=CC=C1)C)C2=CC=CC=C2/N=C/C3=C4C=CC=CC4=CC=C3O |
| Target Point | SIRT1，2 |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | Sirtinol is a specific SIRT1 and SIRT2 inhibitor |
| Biological Activity | Sirtinol 是 sirtuin 的抑制剂，对 ySir2，hSIRT2 和 hSIRT2 的 IC50 值分别为 48 μM，57.7 μM 和 131 μM。[1-4] |
| IC50 | ySir2:48μM;hSIRT2:57.7μM;hSIRT1:131μM [1-4] |
| Data Literature Source | [1]. Wang J，et al. Sirtinol，a class III HDAC inhibitor，induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109. [2]. Fong Y，et al. The antiproliferative and apoptotic effects of sirtinol，a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. [3]. Tsai YF，et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. [4]. Mai A，et al. Design，synthesis，and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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