Poloxamer 407
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Cat.No：IP9010 Solarbio
CAS：9003/11/6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Appearance：White to off-white Solid
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| CAS | 9003/11/6 |
| Name | Poloxamer 407 |
| Molecular Formula | No data available |
| Solubility | Soluble in Water |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 618-355-0 |
| MDL | MFCD00082049 |
| Background | It is a non-ionic surfactant with special reverse thermal gelation, low irritation, good biocompatibility, and is an ideal drug controlled release material |
| In Vivo | In order to efficiently transfer the Adeno-associated virus(AAV)into the vein graft walls and avoid any potential systemic side effects，we used a local delivery method by using poloxamer-407(Solarbio，Beijing China)with trypsin as our previously described [14，15，17]. Briefly，after end to end anastomosis of the vein segment to common carotid artery，30ul AAV6-anti-miR-92a or AAV6-control(Shanghai GeneChem，Co.，Ltd. Shanghai，China)fluid was preloaded into 120 μl 25% poloxamer-407 pluronic gel containing 0.25% trypsin at 4 C，and was gently painted around the grafted vein segments.[1] |
| Data Literature Source | [1]. Zhong CM，Li S，Wang XW，Chen D，Jiang ZL，Zhang C，He XJ，Huang C，Jiang YJ，Wu QC. MicroRNA-92a -mediated endothelial to mesenchymal transition controls vein graft neointimal lesion formation. Exp Cell Res. 2021 Jan 1;398(1):112402 |
| Unit | Bottle |
| Specification | 500mg 1g |
Examples of using this product（for reference only）
In Vivo:
Rabbit ( mature female New Zealand white rabbits (weight 2.5 ±0.5 kg); injected into rabbits with 10 Fr catheter continuously for five days）:
The mature female New Zealand white rabbits (weight 2.5 ±0.5 kg) were maintained under standardized laboratory (temperature 20 ± 2℃, relative humidity 45 ± 10%). Forage and water were qualified.Normal saline, P407 gel, LDH-P407 gel and nonoxinol gel were injected into rabbits with 10 Fr catheter continuously for five days. The rabbits were sacrificed on the sixth day and the vaginal tissues were dissected.
Reference：
Tian W, Han S, Huang X, Han M, Cao J, Liang Y, Sun Y. LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1234-1240. doi: 10.1080/21691401.2019.1596935. Retraction in: Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):555. PMID: 30966834.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Experimental Images
Tian W, et al. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1)1234-1240.
Related Products
Related Paper
MicroRNA-92a -mediated endothelial to mesenchymal transition controls vein graft neointimal lesion formation
Click to check >>Author：Zhong CM;Li S;Wang XW;Chen D;Jiang ZL;Zhang C;He XJ;Huang C;Jiang YJ;Wu QC.
IF：3.7000
Publish_to：Exp Cell Res
PMID：33253710
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