{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > SGI-1776CAS：1025065-69-3
Molecular Formula：C20H22F3N5O
Molecular Weight：405.42
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 1025065-69-3 |
| Name | SGI-1776 |
| Molecular Formula | C20H22F3N5O |
| Molecular Weight | 405.42 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| MDL | MFCD00000398 |
| SMILES | CN1CCC(CC1)CNC2=NN3C(C=C2)=NC=C3C4=CC=CC(OC(F)(F)F)=C4 |
| Target Point | FLT3，Pim1，Pim2，Pim3 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK;JAK/STAT Signaling |
| Background | SGI-1776 is a Pim inhibitor. |
| Biological Activity | SGI-1776 是一种 Pim 抑制剂，抑制 Pim-1，Pim-2 和 Pim-3 的活性，IC50 值分别为 7 nM，363 nM 和 69 nM。[1-4] |
| IC50 | Ki: 7nM(Pim-1)，363nM(Pim-2)，69nM(Pim-3)[4] |
| Data Literature Source | [1]. Hou X，et al. Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Exp Cell Res. 2017 Mar 15;352(2):403-411. [2]. Park YK，et al. The novel anti-adipogenic effect and mechanisms of action of SGI-1776，a Pim-specific inhibitor，in 3T3-L1 adipocytes. Int J Mol Med. 2016 Jan;37(1):157-64 [3]. Xie J，et al. SGI-1776，an imidazo pyridazine compound，inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39(7):649-57 [4]. Chen LS，et al. Mechanisms of cytotoxicity to Pim kinase inhibitor，SGI-1776，in acute myeloid leukemia. Blood，2011，118(3)，693-702 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
