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TG-101209

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Cat.No：IT2050 Solarbio

CAS：936091-14-4

Molecular Formula：C₂₆H₃₅N₇O₂S

Molecular Weight：509.67

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	936091-14-4
Name	TG-101209
Molecular Formula	C₂₆H₃₅N₇O₂S
Molecular Weight	509.67
Solubility	Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 1mg/mL
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00045779
SMILES	O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2C)=C1)(NC(C)(C)C)=O
Target Point	FLT3，JAK2，JAK3，RET
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK
Background	TG101209 is a selective and potent JAK2 inhibitor.
Biological Activity	TG101209 是一种选择性的，有效的 JAK2 抑制剂，IC50 值为 6 nM；同时能抑制 Flt3，和 RET 的活性，IC50 值分别为 25 nM 和 17 nM。[1-4]
Data Literature Source	[1]. Pardanani A，et al. TG101209，a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia. 2007 Aug;21(8):1658-68. [2]. Ma AC，et al. A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Exp Hematol. 2009 Dec;37(12):1379-1386.e4. [3]. Sun Y，et al. Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models. J Thorac Oncol. 2011 Apr;6(4):699-706. [4]. Cuesta-Dominguez A，et al. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PLoS One. 2012;7(2):e32451
Unit	Bottle
Specification	2mg 5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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