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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > Tofacitinib CitrateCAS：540737-29-9
Molecular Formula：C16H20N6O·C6H8O7
Molecular Weight：504.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 540737-29-9 |
| Name | Tofacitinib Citrate |
| Molecular Formula | C16H20N6O·C6H8O7 |
| Molecular Weight | 504.49 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 638-826-4 |
| MDL | MFCD11616529 |
| SMILES | O=C(CC#N)N1C[C@H](N(C2=C3C(NC=C3)=NC=N2)C)[C@H](C)CC1.O=C(CC(C(O)=O)(O)CC(O)=O)O |
| Target Point | JAK |
| Passage | JAK/STAT Signaling |
| Background | Tofacitinib citrate is a JAK1/2/3 inhibitor. |
| Biological Activity | Tofacitinib citrate是 JAK1/2/3 抑制剂，IC50 分别为1，20 和 112 nM。[1-4] |
| Data Literature Source | [1]. Jiang JK，et al. Examining the chirality，conformation and selective kinase inhibition of 3-((3R，4R)-4-methyl-3-(methyl(7H-pyrrolo[2，3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690，550). J Med Chem. 2008 Dec 25;51(24):8012-8. [2]. Onda M，et al. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. J Immunol. 2014 Jul 1;193(1):48-55. [3]. LaBranche TP，et al. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum. 2012 Nov;64(11):3531-42. [4]. Yagi K，et al. Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia. Eur J Pharmacol. 2018 Apr 15;825:28-33 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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