Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > Tofacitinib

Tofacitinib

Manual Download

Cat.No：IT2100 Solarbio

CAS：477600-75-2

Molecular Formula：C₁₆H₂₀N₆O

Molecular Weight：312.37

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	477600-75-2
Name	Tofacitinib
Molecular Formula	C₁₆H₂₀N₆O
Molecular Weight	312.37
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 689-145-4
MDL	MFCD11035919
SMILES	O=C(CC#N)N1C[C@H](N(C2=C3C(NC=C3)=NC=N2)C)[C@H](C)CC1
Target Point	JAK
Passage	JAK/STAT Signaling
Background	Tofacitinib is a JAK1/2/3 inhibitor.
Biological Activity	Tofacitinib是 JAK1/2/3 抑制剂，IC50 分别为1，20 和 112 nM。[1-4]
IC50	JAK3:1nM;JAK2:20nM;JAK1:112nM;Rock-II:3400nM;Lck:3870nM [1-4]
Data Literature Source	[1]. Jiang JK，et al. Examining the chirality，conformation and selective kinase inhibition of 3-((3R，4R)-4-methyl-3-(methyl(7H-pyrrolo[2，3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690，550). J Med Chem. 2008 Dec 25;51(24):8012-8. [2]. Onda M，et al. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. J Immunol. 2014 Jul 1;193(1):48-55. [3]. LaBranche TP，et al. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum. 2012 Nov;64(11):3531-42. [4]. Calama E，et al. Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS. Pulm Pharmacol Ther. 2017 Apr;43:60-67
Unit	Bottle
Specification	10mg 20mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.