WHI-P154
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Cat.No：IW0130 Solarbio
CAS：211555-04-3
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
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PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
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Metabolic Enzyme & Protease
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Ubiquitin
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MAPK
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Hippo
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > WHI-P154
Product Information
| CAS | 211555-04-3 |
| Name | WHI-P154 |
| Molecular Formula | C16H14BrN3O3 |
| Molecular Weight | 376.2 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 809-014-9 |
| MDL | MFCD02179366 |
| SMILES | OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br |
| InChIKey | CBIAKDAYHRWZCU-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20) |
| PubChem CID | 3795 |
| Target Point | EGFR，JAK3 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | WHI-P154 is a potent EGFR inhibitor with modest inhibition of JAK3 activity. |
| Biological Activity | WHI-P154 是一种有效的 EGFR 抑制剂，同时可适度的抑制 JAK3 的活性，IC50 值分别为 4 nM 和 1.8 μM。[1-2] |
| IC50 | EGFR:4nM;JAK3:1.8μM [1-2] |
| In Vitro | WHI-P154是一种有效的EGFR抑制剂，也适度阻断JAK3，IC50分别为4 nM和1.8μM[1]。 WHI-P154显着增强了ABCG2过表达细胞对其底物的敏感性。 WHI-P154(4μM)适度地使ABCB1过表达的KB-C2细胞对其底物敏感，而对ABCC1-，ABCC2或ABCC10-介导的抗药性没有敏感作用。此外，WHI-P154(4μM)导致ABCG2过表达细胞中[3H] - 米诺蒽醌的细胞内积累显着增加。 WHI-P154改变ABCG2过表达细胞中ABCG2蛋白的表达水平而不是定位[2]。 |
| Data Literature Source | [1]. Changelian PS，et al. The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. Epub 2007 Dec 19. [2]. Zhang H，et al. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci. 2014 Aug;105(8):1071-8. |
| Unit | Bottle |
| Specification | 5mg 10mg |
WHI-P154 是一种有效的 EGFR 抑制剂，同时可适度的抑制 JAK3 的活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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