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WP-1066

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Cat.No：IW0150 Solarbio

CAS：857064-38-1

Molecular Formula：C₁₇H₁₄BrN₃O

Molecular Weight：356.22

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	857064-38-1
Name	WP-1066
Molecular Formula	C₁₇H₁₄BrN₃O
Molecular Weight	356.22
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD12912450
SMILES	O=C(N[C@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=NC(Br)=CC=C2
Target Point	JAK2，STAT3
Passage	JAK/STAT Signaling
Background	WP1066 is a novel JAK2 and STAT3 inhibitor.
Biological Activity	WP1066 是一种新颖的 JAK2 和 STAT3 抑制剂，对 STAT5 和 ERK1/2 也起作用，但对 JAK1 和 JAK3 没有影响。[1-3]
Data Literature Source	[1]. Verstovsek S，et al. WP1066，a novel JAK2 inhibitor，suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res，2008，(3)，788-796. [2]. Hatiboglu MA，et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Int J Cancer，2012，131(1)，8-17 [3]. Ferrajoli A，et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res，2007，67(23)，11291-11299
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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