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ZM-39923 Hydrochloride

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Cat.No：IZ0260 Solarbio

CAS：1021868-92-7

Molecular Formula：C₂₃H₂₆ClNO

Molecular Weight：367.91

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	1021868-92-7
Name	ZM-39923 Hydrochloride
Molecular Formula	C₂₃H₂₆ClNO
Molecular Weight	367.91
Solubility	Soluble in DMSO ≥2mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD04974534
SMILES	O=C(C1=CC=C2C=CC=CC2=C1)CCN(C(C)C)CC3=CC=CC=C3.[H]Cl
Target Point	EGFR，JAK，TGM2
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
Background	ZM39923 hydrochloride is a JAK3 inhibitor that also inhibits tissue-type transglutaminase (TGM2) activity.
Biological Activity	ZM39923 hydrochloride 是一种 JAK3 抑制剂， pIC50 值为 7.1；ZM39923 hydrochloride 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50 值为 10 nM。[1-3]
Data Literature Source	[1]. Brown GR，et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. [2]. Lai TS，et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. [3]. Zhang Z，et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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