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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ApremilastCAS：608141-41-9
Molecular Formula：C22H24N2O7S
Molecular Weight：460.5
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 608141-41-9 |
| Name | Apremilast |
| Molecular Formula | C22H24N2O7S |
| Molecular Weight | 460.5 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 807-237-6 |
| MDL | MFCD18782607 |
| SMILES | CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | Apremilast is a phosphodiesterase 4 (PDE4) inhibitor. |
| Biological Activity | Apremilast 是一种磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 74 nM。[1-2] |
| IC50 | 74nM(PDE4)[1] |
| Data Literature Source | [1]. Perez-Aso M，et al. Apremilast，a novel phosphodiesterase 4 (PDE4) inhibitor，regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249. [2]. Chen LG，et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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