English Name |
Anti-UBXN1 Polyclonal Antibody |
Chinese Name |
UBX结构域蛋白1抗体 |
Target |
UBXN1 |
Synonym |
LOC510352B28, 4930455J02Rik, D19Ertd721e, MGC124706, MGC6696, mY33K, UBXN1_HUMAN, Protein 2B28, RGD1309471, SAKS1, SAPK substrate protein 1, T25529, UBA/UBX 33.3 kDa protein, UBX domain containing protein 1, UBX domain protein 1, UBXD10, UBXN1 |
Backgroud |
Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. |
Swiss Prot |
Q04323 |
Gene ID |
51035 |
Subcellular Localization |
Cytoplasm Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
33/35kDa |
Dilution Ratio |
WB 1:1000-3000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human UBXN1 |
Public Immunogen Range |
1-312aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |