Gene Name |
FAS |
English Name |
TNF receptor superfamily, member 6 |
Chinese Name |
肿瘤坏死因子受体超家族成员6 |
Uniprot |
P25445 |
GeneID |
355 |
Predicted Cross Reactivity |
Human Mouse Rat (Bovine Goat Pig Macaque) |
氨基酸大小 |
38kDa |
表达氨基酸 |
1-335aa |
Background |
The protein encoded by this gene is a member of the TNF-receptor superfamily.This receptor contains a death domain.It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10.The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis.This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD).The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
Application |
Immunology research |
Source |
E.coli |
Purification |
NI-NTA affinity purification |
Formulation |
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
Delivery Condition |
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage |
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution |
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity |
Purity≥85% as determined by reducing SDS-PAGE. |
Bioactive |
Not tested. |
Tag information |
With a 6His tag at the N-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |