Gene Name |
STAT3 |
English Name |
signal transducer and activator of transcription 3 |
Chinese Name |
信号传导与转录激活因子3 |
Uniprot |
P40763 |
GeneID |
6774 |
Predicted Cross Reactivity |
Human Mouse Rat (Bovine Pig Chicken) |
氨基酸大小 |
39kDa |
表达氨基酸 |
48-382aa |
Background |
The protein encoded by this gene is a member of the STAT protein family.In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2.This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.The small GTPase Rac1 has been shown to bind and regulate the activity of this protein.PIAS3 protein is a specific inhibitor of this protein.Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Application |
Immunology research |
Source |
E.coli |
Purification |
NI-NTA affinity purification |
Formulation |
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
Delivery Condition |
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage |
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution |
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity |
Purity≥85% as determined by reducing SDS-PAGE. |
Bioactive |
Not tested. |
Tag information |
With a 6His tag at the N-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |